2018
1
Morphology and Motility of Cells on Soft Substrates Preprint
Andriy Goychuk; David B. Brückner; Andrew W. Holle; Joachim P. Spatz; Chase P. Broedersz; Erwin Frey
2018, (Version Number: 2).
Biological PhysicsCell BehaviorCell MigrationCell PolarizationCellular Potts ModelMechanobiologySimulationTraction Force
@preprint{goychuk_morphology_2018,
title = {Morphology and Motility of Cells on Soft Substrates},
author = {Andriy Goychuk and David B. Brückner and Andrew W. Holle and Joachim P. Spatz and Chase P. Broedersz and Erwin Frey},
url = {https://arxiv.org/abs/1808.00314},
doi = {10.48550/ARXIV.1808.00314},
year = {2018},
date = {2018-01-01},
urldate = {2018-01-01},
publisher = {arXiv},
abstract = {Recent experiments suggest that the interplay between cells and the mechanics of their substrate gives rise to a diversity of morphological and migrational behaviors. Here, we develop a Cellular Potts Model of polarizing cells on a visco-elastic substrate. We compare our model with experiments on endothelial cells plated on polyacrylamide hydrogels to constrain model parameters and test predictions. Our analysis reveals that morphology and migratory behavior are determined by an intricate interplay between cellular polarization and substrate strain gradients generated by traction forces exerted by cells (self-haptotaxis).},
note = {Version Number: 2},
keywords = {Biological Physics, Cell Behavior, Cell Migration, Cell Polarization, Cellular Potts Model, Mechanobiology, Simulation, Traction Force},
pubstate = {published},
tppubtype = {preprint}
}
Recent experiments suggest that the interplay between cells and the mechanics of their substrate gives rise to a diversity of morphological and migrational behaviors. Here, we develop a Cellular Potts Model of polarizing cells on a visco-elastic substrate. We compare our model with experiments on endothelial cells plated on polyacrylamide hydrogels to constrain model parameters and test predictions. Our analysis reveals that morphology and migratory behavior are determined by an intricate interplay between cellular polarization and substrate strain gradients generated by traction forces exerted by cells (self-haptotaxis).